ZOLVIX

ZOLVIX® - so effective it kills even resistant worms.  

• Unique mode of action means no Zolvix resistant worm populations exist.  
• Use in every flock every year to kill worms, improve productivity and help manage worm resistance. 
• Only 7 day meat withhold for added marketing flexibility.

When to use and why

ZOLVIX is effective against all economically significant gut worms, both adult, immature and inhibited stages including:

• Barbers pole worm
• Small brown stomach worm
• Stomach hair worm
• Black scour worm
• Small intestinal worm
• Thin-necked intestinal worm
• Large bowel worm
• Large-mouthed bowel worm

Meeting the resistance challenge

Lesley Stubbings, Independent sheep consultant and SCOPS member

“ZOLVIX offers farmers a valuable opportunity to maintain good worm control and prolong the effective life of the existing products. Following the SCOPS guidelines, and carefully integrating ZOLVIX into worm control strategies before the other groups fail, will allow our sheep industry to reap the full benefits of this new novel group.”

The ideal resistance management tool

Every flock, every year

Use ZOLVIX as part of a worm management plan developed for your farm. With its unique mode of action, ZOLVIX is the ideal resistance management tool and can:

• Manage roundworm burdens
• Minimise the development of drench resistance6
• Boost productivity^1,2

Lambs – mid season

• Used mid-season, at or shortly before weaning, ZOLVIX kills resistant worms that may have built up following the use of current classes of drench.
• By removing this burden, lambs benefit at weaning and during fattening, an important growth stage.

Quarantine drench

• ZOLVIX is the ideal quarantine drench.
• No ZOLVIX resistant worm populations exist.
• Buying-in worms resistant to white, yellow and clear classes will limit their use on your farm and increase your reliance on the new 4-AD class.
• ZOLVIX as a quarantine drench helps prevent the arrival of resistant worms on your farm and boost productivity.
• Always follow SCOPS quarantine protocol.

Farms with resistance

• Many farms have worm resistance to the current white (benzimidazole or 1-BZ), yellow (levamisole or 2-LV) and clear (macrocylic lactone or 3-ML) drenches.
• Determine your farm’s resistance status by consulting your vet and using a simple FEC (faecal egg count) test.
• If your farm has diagnosed resistance to any current wormer classes ZOLVIX can be integrated into your worm control programme.
• For farms with triple resistance ZOLVIX and some narrow spectrum wormers may be the mainstay of worm control.

Proven performance

Unparalleled levels of control and certainty*

• Tested on commercial farms in the UK, Europe, New Zealand and Australia, ZOLVIX achieved efficacy of at least 99.9%.³
• A global series of over 20 trials confirmed the broad spectrum efficacy of ZOLVIX against both adult and immature gastrointestinal roundworms.
• ZOLVIX kills resistant and multi-resistant strains. In trials, ZOLVIX and a range of double- and triple-combinations of drenches were used against worm strains such as multi-resistant Haemonchus contortus (Barbers pole worm).
• Whilst some current drenches achieved efficacy as low as 3–5%, ZOLVIX provided worm kill of over 99% against both immature and adult worms.

Offering productivity benefits

ZOLVIX has delivered outstanding results. In trials¹, 280 lambs grazing on pasture with a history of white drench resistance, were treated with ZOLVIX.  Its superior efficacy provided significant productivity benefits¹:

The group treated with ZOLVIX:

•  Had a significantly lower faecal egg count 112 days after treatment.

• A marked improvement in live weight gain compared to the group treated with the white drench albendazole (ABZ).
• Gained 11.2 kg in total - 33.5% more than the albendazole group.
• Had higher mean carcase weights⁴ and a better spread of carcase grades. 
• Based on lamb prices on the day of slaughter, the average price of the ABZ treated animals was 14% lower than those treated with ZOLVIX. 
• Gained 2.8 kg deadweight more on average than the white drench treated group. At the 2009 average price this equates to £9.60/lamb or £4800 per 500 ewe flock⁵.
• Showed a 35% improvement in body condition scores compared to the group treated with albendazole.

Footnote: For example only, productivity gains will vary depending on the level of resistance to traditional wormers and the manner in which Zolvix is used. 

Application

OPTIMUM™ - as revolutionary as ZOLVIX

An integrated backpack, drencher and bottle, revolutionary OPTIMUM makes drenching faster, easier and less tiring.

The OPTILINE™ drencher

Lightweight and user-friendly, the radical design of the OPTILINE drencher ensures drench is delivered accurately and gently to the sheep.

• Designed for improved animal comfort and welfare
• Large, bulbous mouth guard prevents nozzle being inserted too deeply leading to soft tissue damage or rumen bypass.
• Nozzle rotates for left or right handed operators
• Dose dial simple to set, locks automatically
• Adult and lamb nozzle
• More accurate dosing, less wastage

OPTIVIX™ backpack and bottle

• Durable, lightweight weather-proof material
• Adjustable for right/left handed use
• One size adjusts to fit all
• 2 drench cradles – chest and hip level
• Holds all OPTIVIX bottles securely
• 1L and 2.5L

Dosing technique: easier, faster

1. Connect OPTILINE drencher, OPTIVIX bottle and load into OPTIVIX backpack as per instructions.
2. Hold OPTILINE drencher with a relaxed wrist.
3. Drench from behind, with animals facing the same direction as you.
4. Raise animal’s jaw with your spare hand until parallel to the ground. (Not too high, this can interfere with swallowing sending drench into the lungs).
5. The OPTILINE nozzle and mouth guard’s innovative design delivers drench correctly – over the back of the tongue into the rumen. The mouth guard stops the nozzle being inserted too far and damaging the mouth and throat.
6. Check dose accuracy at regular intervals

Dosage

ZOLVIX is a low volume concentrated drench. Dose at 1 ml/10kg

Effective worm kill depends on correct and accurate dosing.

• Dose the flock based on the heaviest sheep in the group being treated.
• If there is a large weight variation, treat as two groups to avoid unnecessary over-dosing.
• Give a full dose orally according to the dosing table. Check the accuracy of your drenching gun before and during use. To ensure effective worm kill, never under-dose any animal.
• Always use the OPTIMUM drenching system and follow the user instructions provided.

Related products

Links

Worms

Datasheet

Click here to view the Zolvix datasheet

Related FAQs

Click here to search for Zolvix entries in our FAQs section

References

* Compared to drenches to which resistance exists.

1. “The production costs of anthelmintic resistance in sheep managed within a monthly preventive drench programme.”  Sutherland, I.A. 1, Bailey, J. 2 and Shaw, R.S.1  1 AgResearch Ltd., The Hopkirk Research Institute and  2 Novartis Animal Health  Australasia.
2. Boost productivity - Zolvix will boost productivity where worm burdens are reducing productivity - the use of a fully effective wormer will improve productivity. Zolvix is known to kill all production limiting roundworms, even those that are resistant to other classes of wormer. Zero resistance – no monepantel resistant nematode populations exist in the field.
3. Kills 99.9% of worms – ‘ZOLVIX in-field efficacy’, New Zealand Study, Novartis Animal Health.
4. Carcase weights for ABZ group averaged 16.0+/-0.55kg (P>0.001), Carcase weights for ZOLVIX group averaged 18.8+/-0.44kg (P>0.001).
5. Sheep Market Outlook, January 2010, Average fourth quarter price of £3.43 in UK.
6. Leathwick, D.M., Hosking, B.C, (2009) Managing Anthelmintic resistance: Modelling the use of a new anthelmintic class to slow the development of resistance to existing classes. New Zealand veterinary Journal 57. 203-207

ZOLVIX contains 25g/L monepantel. ZOLVIX® is a registered trademark of Novartis AG, Basel, Switzerland. Advice on the use of this or alternative medicines must be sought from the medicine prescriber. Use medicines responsibly. Legal category: POM-V.

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